Lansoprazole-induced acute pancreatitis.

A 60-year old male patient was admitted to our emergency department complaining of nausea, vomiting, and abdominal pain. Lansoprazole (Lansor; Sanovel, İstanbul, Turkey) was prescribed to resolve these dyspeptic complaints. However, he suffered from abdominal pain, high fever, nausea, and vomiting an additional two times in the following two weeks. He discontinued treatment since he thought that the symptoms may have been caused by lansoprazole. After he stopped taking the drug, his symptoms decreased and eventually disappeared. During his third hospital admission with the same symptoms, physical examination revealed widespread abdominal tenderness and guarding with decreased bowel sounds. Laboratory test results were compatible with a diagnosis of acute pancreatitis. His electrocardiogram was normal. Computed tomography of the abdomen revealed a slightly enlarged pancreatic corpus and peripancreatic fluid, both of which were compatible with a diagnosis of acute panreatitis (Baltazar A-B level). His current history and laboratory test results eliminated other etiologies, such as viral infections, trauma, alcohol, or toxic causes.